1IMV

2.85 A crystal structure of PEDF

1IMV の概要

• エントリーDOI: 10.2210/pdb1imv/pdb
• 分子名称: PIGMENT EPITHELIUM-DERIVED FACTOR, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: serpin, pedf, angiogenesis, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44549.72

構造登録者

Simonovic, M.,Gettins, P.G.W.,Volz, K. (登録日: 2001-05-11, 公開日: 2001-09-26, 最終更新日: 2024-10-30)

主引用文献

Simonovic, M.,Gettins, P.G.,Volz, K.
Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor.
Proc.Natl.Acad.Sci.USA, 98:11131-11135, 2001

PubMed Abstract: Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serpin superfamily, is the most potent inhibitor of angiogenesis in the mammalian ocular compartment. It also has neurotrophic activity, both in the retina and in the central nervous system, and is highly up-regulated in young versus senescent fibroblasts. To provide a structural basis for understanding its many biological roles, we have solved the crystal structure of glycosylated human PEDF to 2.85 A. The structure revealed the organization of possible receptor and heparin-binding sites, and showed that, unlike any other previously characterized serpin, PEDF has a striking asymmetric charge distribution that might be of functional importance. These results provide a starting point for future detailed structure/function analyses into possible mechanisms of PEDF action that could lead to development of therapeutics against uncontrolled angiogenesis.

PubMed: 11562499
DOI: 10.1073/pnas.211268598

実験手法

X-RAY DIFFRACTION (2.85 Å)