1ILP

CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8

Summary for 1ILP

• Entry DOI: 10.2210/pdb1ilp/pdb
• Descriptor: Interleukin-8 (precursor), C-X-C chemokine receptor type 1 (2 entities in total)
• Functional Keywords: cytokine
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 18871.83

Authors

Skelton, N.J.,Quan, C.,Lowman, H. (deposition date: 1998-12-16, release date: 1998-12-23, Last modification date: 2024-11-20)

Primary citation

Skelton, N.J.,Quan, C.,Reilly, D.,Lowman, H.
Structure of a CXC chemokine-receptor fragment in complex with interleukin-8.
Structure Fold.Des., 7:157-168, 1999

PubMed Abstract: Interactions between CXC chemokines (e.g. interleukin-8, IL-8) and their receptors (e.g. CXCR-1) have a key role in host defense and disease by attracting and upregulating neutrophils to sites of inflammation. The transmembrane nature of the receptor impedes structure-based understanding of ligand interactions. Linear peptides based on the N-terminal, extracellular portion of the receptor CXCR-1 do bind to IL-8, however, and inhibit the binding of IL-8 to the full-length receptor.

PubMed: 10368283
DOI: 10.1016/S0969-2126(99)80022-7

Experimental method

SOLUTION NMR