1ILP

CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8

1ILP の概要

• エントリーDOI: 10.2210/pdb1ilp/pdb
• 分子名称: Interleukin-8 (precursor), C-X-C chemokine receptor type 1 (2 entities in total)
• 機能のキーワード: cytokine
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 18871.83

構造登録者

Skelton, N.J.,Quan, C.,Lowman, H. (登録日: 1998-12-16, 公開日: 1998-12-23, 最終更新日: 2024-11-20)

主引用文献

Skelton, N.J.,Quan, C.,Reilly, D.,Lowman, H.
Structure of a CXC chemokine-receptor fragment in complex with interleukin-8.
Structure Fold.Des., 7:157-168, 1999

PubMed Abstract: Interactions between CXC chemokines (e.g. interleukin-8, IL-8) and their receptors (e.g. CXCR-1) have a key role in host defense and disease by attracting and upregulating neutrophils to sites of inflammation. The transmembrane nature of the receptor impedes structure-based understanding of ligand interactions. Linear peptides based on the N-terminal, extracellular portion of the receptor CXCR-1 do bind to IL-8, however, and inhibit the binding of IL-8 to the full-length receptor.

PubMed: 10368283
DOI: 10.1016/S0969-2126(99)80022-7

実験手法

SOLUTION NMR