1IGR

Type 1 Insulin-like growth factor receptor (DOMAINS 1-3)

1IGR の概要

• エントリーDOI: 10.2210/pdb1igr/pdb
• 分子名称: INSULIN-LIKE GROWTH FACTOR RECEPTOR 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: hormone receptor, insulin receptor family
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57070.03

構造登録者

Garrett, T.P.J.,Mckern, N.M.,Lou, M.,Frenkel, M.J.,Bentley, J.D.,Lovrecz, G.O.,Elleman, T.C.,Cosgrove, L.J.,Ward, C.W. (登録日: 1998-09-28, 公開日: 1999-09-27, 最終更新日: 2024-10-30)

主引用文献

Garrett, T.P.,McKern, N.M.,Lou, M.,Frenkel, M.J.,Bentley, J.D.,Lovrecz, G.O.,Elleman, T.C.,Cosgrove, L.J.,Ward, C.W.
Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.
Nature, 394:395-399, 1998

PubMed Abstract: The type-1 insulin-like growth-factor receptor (IGF-1R) and insulin receptor (IR) are closely related members of the tyrosine-kinase receptor superfamily. IR is essential for glucose homeostasis, whereas IGF-1R is involved in both normal growth and development and malignant transformation. Homologues of these receptors are found in animals as simple as cnidarians. The epidermal growth-factor receptor (EGFR) family is closely related to the IR family and has significant sequence identity to the extracellular portion we describe here. We now present the structure of the first three domains of IGF-IR (L1-Cys-rich-L2) determined to 2.6 A resolution. The L domains each consist of a single-stranded right-handed beta-helix. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain with modules associated in an unusual manner. The three domains surround a central space of sufficient size to accommodate a ligand molecule. Although the fragment (residues 1-462) does not bind ligand, many of the determinants responsible for hormone binding and ligand specificity map to this central site. This structure therefore shows how the IR subfamily might interact with their ligands.

PubMed: 9690478
DOI: 10.1038/28668

実験手法

X-RAY DIFFRACTION (2.6 Å)