1IEB

HISTOCOMPATIBILITY ANTIGEN

1IEB の概要

• エントリーDOI: 10.2210/pdb1ieb/pdb
• 分子名称: MHC CLASS II I-EK, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: histocompatibility antigen
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 98686.09

構造登録者

Fremont, D.H.,Hendrickson, W.A.,Marrack, P.,Kappler, J. (登録日: 1996-04-05, 公開日: 1997-06-05, 最終更新日: 2024-11-06)

主引用文献

Fremont, D.H.,Hendrickson, W.A.,Marrack, P.,Kappler, J.
Structures of an MHC class II molecule with covalently bound single peptides.
Science, 272:1001-1004, 1996

PubMed Abstract: The high-resolution x-ray crystal structures of the murine major histocompatibility complex (MHC) class II molecule, I-E(k), occupied by either of two antigenic peptides were determined. They reveal the structural basis for the I-E(k) peptide binding motif and suggest general principles for additional alleles. A buried cluster of acidic amino acids in the binding groove predicted to be conserved among all murine I-E and human DR MHC class II molecules suggests how pH may influence MHC binding or exchange of peptides. These structures also complement mutational studies on the importance of individual peptide residues to T cell receptor recognition.

PubMed: 8638119

実験手法

X-RAY DIFFRACTION (2.7 Å)