1IDB

Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere

Summary for 1IDB

• Entry DOI: 10.2210/pdb1idb/pdb
• Related: 1IDA
• Related PRD ID: PRD_000244
• Descriptor: Protease, (2R,4S)-N-tert-butyl-1-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutyl]-4-(pyridin-4-ylsulfonyl)piperidine-2-carboxamide (3 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 2
• Total number of polymer chains: 2
• Total formula weight: 22107.50

Authors

Tong, L.,Anderson, P.C. (deposition date: 1994-10-19, release date: 1995-01-26, Last modification date: 2024-02-07)

• Primary citation: Tong, L.,Pav, S.,Mui, S.,Lamarre, D.,Yoakim, C.,Beaulieu, P.,Anderson, P.C.; Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.; Structure, 3:33-40, 1995; PubMed: 7743130; DOI: 10.1016/S0969-2126(01)00133-2

Experimental method

X-RAY DIFFRACTION (2.2 Å)