1I8D

CRYSTAL STRUCTURE OF RIBOFLAVIN SYNTHASE

1I8D の概要

• エントリーDOI: 10.2210/pdb1i8d/pdb
• 分子名称: RIBOFLAVIN SYNTHASE (2 entities in total)
• 機能のキーワード: riboflavin synthase, riboflavin biosynthesis, antimicrobial target, structure-based design, escherichia coli, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70418.65

構造登録者

Liao, D.-I.,Wawrzak, Z.,Calabrese, J.C.,Viitanen, P.V.,Jordan, D.B. (登録日: 2001-03-13, 公開日: 2001-09-19, 最終更新日: 2024-02-07)

主引用文献

Liao, D.I.,Wawrzak, Z.,Calabrese, J.C.,Viitanen, P.V.,Jordan, D.B.
Crystal structure of riboflavin synthase.
Structure, 9:399-408, 2001

PubMed Abstract: Riboflavin synthase catalyzes the dismutation of two molecules of 6,7-dimethyl-8-(1'-D-ribityl)-lumazine to yield riboflavin and 4-ribitylamino-5-amino-2,6-dihydroxypyrimidine. The homotrimer of 23 kDa subunits has no cofactor requirements for catalysis. The enzyme is nonexistent in humans and is an attractive target for antimicrobial agents of organisms whose pathogenicity depends on their ability to biosynthesize riboflavin.

PubMed: 11377200
DOI: 10.1016/S0969-2126(01)00600-1

実験手法

X-RAY DIFFRACTION (2 Å)