1I4F

CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX

1I4F の概要

• エントリーDOI: 10.2210/pdb1i4f/pdb
• 関連するPDBエントリー: 1qew
• 分子名称: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2-MICROGLOBULIN, MELANOMA-ASSOCIATED ANTIGEN 4, ... (5 entities in total)
• 機能のキーワード: major histocompatibility complex, human leukocyte antigen, melanoma-associated antigen, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45372.37

構造登録者

Hillig, R.C.,Coulie, P.G.,Stroobant, V.,Saenger, W.,Ziegler, A.,Huelsmeyer, M. (登録日: 2001-02-21, 公開日: 2001-07-25, 最終更新日: 2024-10-16)

主引用文献

Hillig, R.C.,Coulie, P.G.,Stroobant, V.,Saenger, W.,Ziegler, A.,Hulsmeyer, M.
High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene.
J.Mol.Biol., 310:1167-1176, 2001

PubMed Abstract: The heterotrimeric complex of the human major histocompatibity complex (MHC) molecule HLA-A*0201, beta2-microglobulin and the decameric peptide GVYDGREHTV derived from the melanoma antigen (MAGE-A4 protein has been determined by X-ray crystallography at 1.4 A resolution. MAGE-A4 belongs to a family of genes that are specifically expressed in a variety of tumours. MAGE-A4-derived peptides are presented by MHC molecules at the cell surface to cytotoxic T-lymphocytes. As the HLA-A*0201:MAGE-A4 complex occurs only on tumour cells, it is considered to be an appropriate target for immunotherapy. The structure presented here reveals potential epitopes specific to the complex and indicates which peptide residues could be recognised by T-cell receptors. In addition, as the structure could be refined anisotropically, it was possible to describe the movements of the bound peptide in more detail.

PubMed: 11502003
DOI: 10.1006/jmbi.2001.4816

実験手法

X-RAY DIFFRACTION (1.4 Å)