1I2Z

E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654

Summary for 1I2Z

Entry DOI	10.2210/pdb1i2z/pdb
Related	1C14 1I30
Descriptor	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-THIENYL)-1-(4-METHYLBENZYL)-1H-IMIDAZOLE, ... (4 entities in total)
Functional Keywords	enoyl reductase, nad, antibiotic, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	57621.40
Authors	Heerding, D.A.,Miller, W.H.,Payne, D.J.,Janson, C.A.,Qiu, X. (deposition date: 2001-02-12, release date: 2002-02-12, Last modification date: 2024-02-07)
Primary citation	Heerding, D.A.,Chan, G.,DeWolf, W.E.,Fosberry, A.P.,Janson, C.A.,Jaworski, D.D.,McManus, E.,Miller, W.H.,Moore, T.D.,Payne, D.J.,Qiu, X.,Rittenhouse, S.F.,Slater-Radosti, C.,Smith, W.,Takata, D.T.,Vaidya, K.S.,Yuan, C.C.,Huffman, W.F. 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Bioorg.Med.Chem.Lett., 11:2061-2065, 2001 Cited by PubMed: 11514139 DOI: 10.1016/S0960-894X(01)00404-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation