1I2Z

E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654

1I2Z の概要

• エントリーDOI: 10.2210/pdb1i2z/pdb
• 関連するPDBエントリー: 1C14 1I30
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-THIENYL)-1-(4-METHYLBENZYL)-1H-IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: enoyl reductase, nad, antibiotic, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57621.40

構造登録者

Heerding, D.A.,Miller, W.H.,Payne, D.J.,Janson, C.A.,Qiu, X. (登録日: 2001-02-12, 公開日: 2002-02-12, 最終更新日: 2024-02-07)

• 主引用文献: Heerding, D.A.,Chan, G.,DeWolf, W.E.,Fosberry, A.P.,Janson, C.A.,Jaworski, D.D.,McManus, E.,Miller, W.H.,Moore, T.D.,Payne, D.J.,Qiu, X.,Rittenhouse, S.F.,Slater-Radosti, C.,Smith, W.,Takata, D.T.,Vaidya, K.S.,Yuan, C.C.,Huffman, W.F.; 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).; Bioorg.Med.Chem.Lett., 11:2061-2065, 2001; PubMed: 11514139; DOI: 10.1016/S0960-894X(01)00404-8

実験手法

X-RAY DIFFRACTION (2.8 Å)