1HZD

CRYSTAL STRUCTURE OF HUMAN AUH PROTEIN, AN RNA-BINDING HOMOLOGUE OF ENOYL-COA HYDRATASE

1HZD の概要

• エントリーDOI: 10.2210/pdb1hzd/pdb
• 関連するPDBエントリー: 1DCI 1DUB
• 分子名称: AU-BINDING PROTEIN/ENOYL-COA HYDRATASE (2 entities in total)
• 機能のキーワード: rna-binding protein, enoyl-coa hydratase, riken structural genomics/proteomics initiative, rsgi, structural genomics, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 175428.92

構造登録者

Kurimoto, K.,Fukai, S.,Nureki, O.,Muto, Y.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2001-01-24, 公開日: 2001-12-12, 最終更新日: 2023-08-09)

主引用文献

Kurimoto, K.,Fukai, S.,Nureki, O.,Muto, Y.,Yokoyama, S.
Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase.
Structure, 9:1253-1263, 2001

PubMed Abstract: The AU binding homolog of enoyl-CoA hydratase (AUH) is a bifunctional protein that has two distinct activities: AUH binds to RNA and weakly catalyzes the hydration of 2-trans-enoyl-coenzyme A (enoyl-CoA). AUH has no sequence similarity with other known RNA binding proteins, but it has considerable sequence similarity with enoyl-CoA hydratase. A segment of AUH, named the R peptide, binds to RNA. However, the mechanism of the RNA binding activity of AUH remains to be elucidated.

PubMed: 11738050
DOI: 10.1016/S0969-2126(01)00686-4

実験手法

X-RAY DIFFRACTION (2.2 Å)