1HVS
STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING
Summary for 1HVS
Entry DOI | 10.2210/pdb1hvs/pdb |
Descriptor | HIV-1 PROTEASE, N-{1-BENZYL-(2R,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE (2 entities in total) |
Functional Keywords | hydrolase (acid protease) |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587 |
Total number of polymer chains | 2 |
Total formula weight | 22346.38 |
Authors | Baldwin, E.T.,Bhat, T.N.,Liu, B.,Pattabiraman, N.,Erickson, J.W. (deposition date: 1994-11-17, release date: 1995-02-14, Last modification date: 2024-02-07) |
Primary citation | Baldwin, E.T.,Bhat, T.N.,Liu, B.,Pattabiraman, N.,Erickson, J.W. Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase. Nat.Struct.Biol., 2:244-249, 1995 Cited by PubMed: 7773792DOI: 10.1038/nsb0395-244 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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