1HVH

NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS

1HVH の概要

• エントリーDOI: 10.2210/pdb1hvh/pdb
• 分子名称: HIV-1 PROTEASE, {[4-R(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS(4-HYDROXYMETHYL)METHYL]-4,7-BIS(PHENYLMETHYL) -2H-1,3-DIAZEPIN-2-YLIDENE]CYANAMIDE} (3 entities in total)
• 機能のキーワード: hydrolase, acid protease
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22106.04

構造登録者

Chang, C.-H. (登録日: 1997-12-13, 公開日: 1998-12-30, 最終更新日: 2024-05-22)

• 主引用文献: Jadhav, P.K.,Woerner, F.J.,Lam, P.Y.,Hodge, C.N.,Eyermann, C.J.,Man, H.W.,Daneker, W.F.,Bacheler, L.T.,Rayner, M.M.,Meek, J.L.,Erickson-Viitanen, S.,Jackson, D.A.,Calabrese, J.C.,Schadt, M.,Chang, C.H.; Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.; J.Med.Chem., 41:1446-1455, 1998; PubMed: 9554878; DOI: 10.1021/jm970524i

実験手法

X-RAY DIFFRACTION (1.8 Å)