1HTJ

STRUCTURE OF THE RGS-LIKE DOMAIN FROM PDZ-RHOGEF

1HTJ の概要

• エントリーDOI: 10.2210/pdb1htj/pdb
• 分子名称: KIAA0380 (2 entities in total)
• 機能のキーワード: rgs-like, regulator of g protein signaling, gef, guanine nucleotide exchange factor, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23901.24

構造登録者

Longenecker, K.L.,Lewis, M.E.,Chikumi, H.,Gutkind, J.S.,Derewenda, Z.S. (登録日: 2000-12-29, 公開日: 2001-07-11, 最終更新日: 2024-11-13)

主引用文献

Longenecker, K.L.,Lewis, M.E.,Chikumi, H.,Gutkind, J.S.,Derewenda, Z.S.
Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.
Structure, 9:559-569, 2001

PubMed Abstract: The multidomain PDZ-RhoGEF is one of many known guanine nucleotide exchange factors that upregulate Rho GTPases. PDZ-RhoGEF and related family members play a critical role in a molecular signaling pathway from heterotrimeric G protein-coupled receptors to Rho proteins. A approximately 200 residue RGS-like (RGSL) domain in PDZ-RhoGEF and its homologs is responsible for the direct association with Galpha12/13 proteins. To better understand structure-function relationships, we initiated crystallographic studies of the RGSL domain from human PDZ-RhoGEF.

PubMed: 11470431
DOI: 10.1016/S0969-2126(01)00620-7

実験手法

X-RAY DIFFRACTION (2.2 Å)