1HTG
X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
1HTG の概要
エントリーDOI | 10.2210/pdb1htg/pdb |
分子名称 | HIV-1 PROTEASE, 2-(BENZYLCARBAMOYL-PHENYLACETYLAMINO-METHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID 3-[(1H-BENZIMIDAZOL-2-YLMETHYLCARBAMOYL)-1-BENZYL-2-HYDROXYPROPYL]-AMIDE (3 entities in total) |
機能のキーワード | hydrolase(acid proteinase) |
由来する生物種 | Human immunodeficiency virus 1 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 23131.37 |
構造登録者 | |
主引用文献 | Jhoti, H.,Singh, O.M.,Weir, M.P.,Cooke, R.,Murray-Rust, P.,Wonacott, A. X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease. Biochemistry, 33:8417-8427, 1994 Cited by PubMed: 8031777DOI: 10.1021/bi00194a005 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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