1HSI

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES

Summary for 1HSI

Entry DOI	10.2210/pdb1hsi/pdb
Descriptor	HIV-2 PROTEASE (2 entities in total)
Functional Keywords	hydrolase (acid proteinase)
Biological source	Human immunodeficiency virus 2
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584
Total number of polymer chains	2
Total formula weight	21456.67
Authors	Chen, Z. (deposition date: 1995-03-31, release date: 1996-04-03, Last modification date: 2024-02-07)
Primary citation	Chen, Z.,Li, Y.,Chen, E.,Hall, D.L.,Darke, P.L.,Culberson, C.,Shafer, J.A.,Kuo, L.C. Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J.Biol.Chem., 269:26344-26348, 1994 Cited by PubMed: 7929352 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation