1HSH
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
1HSH の概要
エントリーDOI | 10.2210/pdb1hsh/pdb |
分子名称 | HIV-II PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE (3 entities in total) |
機能のキーワード | hydrolase (acid proteinase), hydrolase |
由来する生物種 | Human immunodeficiency virus 2 (HIV-2) |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 44140.93 |
構造登録者 | |
主引用文献 | Chen, Z.,Li, Y.,Chen, E.,Hall, D.L.,Darke, P.L.,Culberson, C.,Shafer, J.A.,Kuo, L.C. Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J.Biol.Chem., 269:26344-26348, 1994 Cited by PubMed: 7929352主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)