1HSG

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES

1HSG の概要

• エントリーDOI: 10.2210/pdb1hsg/pdb
• 分子名称: HIV-1 PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE (3 entities in total)
• 機能のキーワード: hydrolase (acid proteinase)
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22221.30

構造登録者

Chen, Z. (登録日: 1995-03-31, 公開日: 1996-04-03, 最終更新日: 2024-02-07)

• 主引用文献: Chen, Z.,Li, Y.,Chen, E.,Hall, D.L.,Darke, P.L.,Culberson, C.,Shafer, J.A.,Kuo, L.C.; Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.; J.Biol.Chem., 269:26344-26348, 1994; PubMed: 7929352

実験手法

X-RAY DIFFRACTION (2 Å)