1HQ5

CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH S-(2-BORONOETHYL)-L-CYSTEINE, AN L-ARGININE ANALOGUE

Summary for 1HQ5

Entry DOI	10.2210/pdb1hq5/pdb
Related	1D3V 1RLA
Descriptor	ARGINASE 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE, ... (4 entities in total)
Functional Keywords	binuclear manganese cluster, boronic acid inhibitor, perfectly twinned crystal, hydrolase
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Cytoplasm : P07824
Total number of polymer chains	2
Total formula weight	70678.02
Authors	Kim, N.N.,Cox, J.D.,Baggio, R.F.,Emig, F.A.,Mistry, S.K.,Harper, S.L.,Speicher, D.W.,Morris Jr., S.M.,Ash, D.E.,Traish, A.,Christianson, D.W. (deposition date: 2000-12-14, release date: 2001-04-04, Last modification date: 2024-02-07)
Primary citation	Kim, N.N.,Cox, J.D.,Baggio, R.F.,Emig, F.A.,Mistry, S.K.,Harper, S.L.,Speicher, D.W.,Morris Jr., S.M.,Ash, D.E.,Traish, A.,Christianson, D.W. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry, 40:2678-2688, 2001 Cited by PubMed: 11258879 DOI: 10.1021/bi002317h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation