1HPX

HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272

1HPX の概要

• エントリーDOI: 10.2210/pdb1hpx/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000562
• 分子名称: HIV-1 PROTEASE, (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide (3 entities in total)
• 機能のキーワード: acid protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22275.35

構造登録者

Bhat, T.N.,Erickson, J.W. (登録日: 1995-05-18, 公開日: 1996-03-08, 最終更新日: 2024-02-07)

• 主引用文献: Baldwin, E.T.,Bhat, T.N.,Gulnik, S.,Liu, B.,Topol, I.A.,Kiso, Y.,Mimoto, T.,Mitsuya, H.,Erickson, J.W.; Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine.; Structure, 3:581-590, 1995; PubMed: 8590019; DOI: 10.1016/S0969-2126(01)00192-7

実験手法

X-RAY DIFFRACTION (2 Å)