1HOS
INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS
Summary for 1HOS
Entry DOI | 10.2210/pdb1hos/pdb |
Descriptor | HIV-1 PROTEASE, (2-PHENYL-1-CARBOBENZYL-OXYVALYL-AMINO)-ETHYL-PHOSPHINIC ACID (3 entities in total) |
Functional Keywords | hydrolase(acid proteinase) |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22378.36 |
Authors | Abdel-Meguid, S.,Zhao, B. (deposition date: 1993-04-06, release date: 1993-10-31, Last modification date: 2024-02-07) |
Primary citation | Abdel-Meguid, S.S.,Zhao, B.,Murthy, K.H.,Winborne, E.,Choi, J.K.,DesJarlais, R.L.,Minnich, M.D.,Culp, J.S.,Debouck, C.,Tomaszek Jr., T.A.,Meek, T.D.,Dreyer, G.B. Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. Synthesis and crystallographic analysis. Biochemistry, 32:7972-7980, 1993 Cited by PubMed: 8347601DOI: 10.1021/bi00082a019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report