1HMY

CRYSTAL STRUCTURE OF THE HHAI DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE

Summary for 1HMY

Entry DOI	10.2210/pdb1hmy/pdb
Descriptor	HaeIII METHYLTRANSFERASE, S-ADENOSYLMETHIONINE (2 entities in total)
Functional Keywords	transferase(methyltransferase)
Biological source	Haemophilus haemolyticus
Total number of polymer chains	1
Total formula weight	37440.64
Authors	Cheng, X. (deposition date: 1993-08-05, release date: 1993-10-31, Last modification date: 2024-06-05)
Primary citation	Cheng, X.,Kumar, S.,Posfai, J.,Pflugrath, J.W.,Roberts, R.J. Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. Cell(Cambridge,Mass.), 74:299-307, 1993 Cited by PubMed Abstract: The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function. PubMed: 8343957 DOI: 10.1016/0092-8674(93)90421-L PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation