1HMY

CRYSTAL STRUCTURE OF THE HHAI DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE

1HMY の概要

• エントリーDOI: 10.2210/pdb1hmy/pdb
• 分子名称: HaeIII METHYLTRANSFERASE, S-ADENOSYLMETHIONINE (2 entities in total)
• 機能のキーワード: transferase(methyltransferase)
• 由来する生物種: Haemophilus haemolyticus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37440.64

構造登録者

Cheng, X. (登録日: 1993-08-05, 公開日: 1993-10-31, 最終更新日: 2024-06-05)

主引用文献

Cheng, X.,Kumar, S.,Posfai, J.,Pflugrath, J.W.,Roberts, R.J.
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.
Cell(Cambridge,Mass.), 74:299-307, 1993

PubMed Abstract: The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.

PubMed: 8343957
DOI: 10.1016/0092-8674(93)90421-L

実験手法

X-RAY DIFFRACTION (2.5 Å)