1HM3

ACTIVE SITE OF CHONDROITINASE AC LYASE REVEALED BY THE STRUCTURE OF ENZYME-OLIGOSACCHARIDE COMPLEXES AND MUTAGENESIS

1HM3 の概要

• エントリーDOI: 10.2210/pdb1hm3/pdb
• 関連するPDBエントリー: 1HM2 1HMU 1HMW
• 分子名称: CHONDROITINASE AC, 2-O-methyl-beta-L-fucopyranose-(1-4)-beta-D-xylopyranose-(1-4)-alpha-D-glucopyranuronic acid-(1-2)-[alpha-L-rhamnopyranose-(1-4)]alpha-D-mannopyranose, alpha-D-glucopyranuronic acid-(1-2)-[alpha-L-rhamnopyranose-(1-4)]alpha-D-mannopyranose, ... (6 entities in total)
• 機能のキーワード: protein-oligosaccharide complex, active site, catalysis, lyase
• 由来する生物種: Pedobacter heparinus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 81532.24

構造登録者

Huang, W.,Boju, L.,Tkalec, L.,Su, H.,Yang, H.O.,Gunay, N.S.,Linhardt, R.J.,Kim, Y.S.,Matte, A.,Cygler, M. (登録日: 2000-12-04, 公開日: 2001-05-02, 最終更新日: 2020-07-29)

• 主引用文献: Huang, W.,Boju, L.,Tkalec, L.,Su, H.,Yang, H.O.,Gunay, N.S.,Linhardt, R.J.,Kim, Y.S.,Matte, A.,Cygler, M.; Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.; Biochemistry, 40:2359-2372, 2001; PubMed: 11327856; DOI: 10.1021/bi0024254

実験手法

X-RAY DIFFRACTION (2.1 Å)