1HKF

The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity

1HKF の概要

• エントリーDOI: 10.2210/pdb1hkf/pdb
• 分子名称: NK CELL ACTIVATING RECEPTOR (2 entities in total)
• 機能のキーワード: natural cytotoxicity receptor, nkp44, receptor, immunoglobulin domain
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein (Potential): O95944
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13957.73

構造登録者

Ponassi, M.,Cantoni, C.,Biassoni, R.,Conte, R.,Spallarossa, A.,Moretta, A.,Moretta, L.,Bolognesi, M.,Bordo, D. (登録日: 2003-03-10, 公開日: 2003-06-11, 最終更新日: 2024-10-23)

主引用文献

Cantoni, C.,Ponassi, M.,Biassoni, R.,Conte, R.,Spallarossa, A.,Moretta, A.,Moretta, L.,Bolognesi, M.,Bordo, D.
The Three-Dimensional Structure of the Human Nk Cell Receptor Nkp44, a Triggering Partner in Natural Cytotoxicity
Structure, 11:725-, 2003

PubMed Abstract: Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.

PubMed: 12791260
DOI: 10.1016/S0969-2126(03)00095-9

実験手法

X-RAY DIFFRACTION (2.2 Å)