1HIV

CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING

1HIV の概要

• エントリーDOI: 10.2210/pdb1hiv/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000403
• 分子名称: HIV-1 PROTEASE, 4-[(2R)-3-{[(1S,2S,3R,4S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methyl-4-({(1S,2R)-2-methyl-1-[(pyridin-2-ylmethyl)carbamoyl]butyl}carbamoyl)hexyl]amino}-2-{[(naphthalen-1-yloxy)acetyl]amino}-3-oxopropyl]-1H-imidazol-3-ium (3 entities in total)
• 機能のキーワード: acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22424.47

構造登録者

Thanki, N.,Wlodawer, A. (登録日: 1992-02-12, 公開日: 1993-10-31, 最終更新日: 2017-11-29)

• 主引用文献: Thanki, N.,Rao, J.K.,Foundling, S.I.,Howe, W.J.,Moon, J.B.,Hui, J.O.,Tomasselli, A.G.,Heinrikson, R.L.,Thaisrivongs, S.,Wlodawer, A.; Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling.; Protein Sci., 1:1061-1072, 1992; PubMed: 1304383

実験手法

X-RAY DIFFRACTION (2 Å)