1HFZ

ALPHA-LACTALBUMIN

1HFZ の概要

• エントリーDOI: 10.2210/pdb1hfz/pdb
• 分子名称: ALPHA-LACTALBUMIN, CALCIUM ION (3 entities in total)
• 機能のキーワード: lactose synthase component, calcium binding metalloprotein, lactose, glycoprotein
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted: P00711
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 57365.03

構造登録者

Pike, A.C.W.,Brew, K.,Acharya, K.R. (登録日: 1996-06-13, 公開日: 1997-07-29, 最終更新日: 2024-10-09)

主引用文献

Pike, A.C.,Brew, K.,Acharya, K.R.
Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase.
Structure, 4:691-703, 1996

PubMed Abstract: The regulation of milk lactose biosynthesis is highly dependent on the action of a specifier protein, alpha-lactalbumin (LA). Together with a glycosyltransferase, LA forms the enzyme complex lactose synthase. LA promotes the binding of glucose to the complex and facilitates the biosynthesis of lactose. To gain further insight into the molecular basis of LA function in lactose synthase we have determined the structures of three species variants of LA.

PubMed: 8805552
DOI: 10.1016/S0969-2126(96)00075-5

実験手法

X-RAY DIFFRACTION (2.3 Å)