1HEG

The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations

1HEG の概要

• エントリーDOI: 10.2210/pdb1heg/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000320
• 分子名称: HIV-1 PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate (3 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11364.38

構造登録者

Murthy, K.,Winborne, E.L.,Minnich, M.D.,Culp, J.S.,Debouck, C. (登録日: 1992-09-21, 公開日: 1994-05-31, 最終更新日: 2024-03-13)

• 主引用文献: Murthy, K.H.,Winborne, E.L.,Minnich, M.D.,Culp, J.S.,Debouck, C.; The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations.; J.Biol.Chem., 267:22770-22778, 1992; PubMed: 1429626

実験手法

X-RAY DIFFRACTION (2.2 Å)