1HDM

HISTOCOMPATIBILITY ANTIGEN HLA-DM

Summary for 1HDM

• Entry DOI: 10.2210/pdb1hdm/pdb
• Descriptor: PROTEIN (CLASS II HISTOCOMPATIBILITY ANTIGEN, M ALPHA CHAIN), PROTEIN (CLASS II HISTOCOMPATIBILITY ANTIGEN, M BETA CHAIN) (2 entities in total)
• Functional Keywords: histocompatibility protein, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Late endosome membrane; Single-pass type I membrane protein: P28067 P28068
• Total number of polymer chains: 2
• Total formula weight: 44464.08

Authors

Wiley, D.C.,Mosyak, L. (deposition date: 1998-09-09, release date: 1999-09-10, Last modification date: 2024-11-20)

Primary citation

Mosyak, L.,Zaller, D.M.,Wiley, D.C.
The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.
Immunity, 9:377-383, 1998

PubMed Abstract: The three-dimensional structure of the soluble ecto-domain of HLA-DM has been determined to 2.5 A resolution by X-ray crystallography. HLA-DM has both peptide exchange activity and acts as a chaperone to peptide-free class II MHC molecules. As predicted, the structure is similar to that of classical class II MHC molecules except that the peptide-binding site is altered to an almost fully closed groove. An unusual cavity is found at the center of the region that binds peptides in class II MHC molecules, and a tryptophanrich lateral surface is identified that is a candidate both for binding to HLA-DR, to effect catalysis, and to HLA-DO, an inhibitor.

PubMed: 9768757
DOI: 10.1016/S1074-7613(00)80620-2

Experimental method

X-RAY DIFFRACTION (2.5 Å)