1HBV

A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC

Summary for 1HBV

Entry DOI	10.2210/pdb1hbv/pdb
Descriptor	HIV-1 PROTEASE, 2-[3-BENZYL-5-(1-ALANYL-AMINOETHYL)-2,3,6,7-TETRAHYDRO-1H-AZEPIN-1-YL]-1-OXOPROPYL-VALINYL-VALINE-METHYLESTER (3 entities in total)
Functional Keywords	hydrolase (acid protease)
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
Total number of polymer chains	2
Total formula weight	22193.29
Authors	Hoog, S.,Abdel-Meguid, S. (deposition date: 1995-03-29, release date: 1995-07-10, Last modification date: 2024-02-07)
Primary citation	Hoog, S.S.,Zhao, B.,Winborne, E.,Fisher, S.,Green, D.W.,DesJarlais, R.L.,Newlander, K.A.,Callahan, J.F.,Moore, M.L.,Huffman, W.F.,Abdel-Meguid, S.S. A check on rational drug design: crystal structure of a complex of human immunodeficiency virus type 1 protease with a novel gamma-turn mimetic inhibitor. J.Med.Chem., 38:3246-3252, 1995 Cited by PubMed: 7650677 DOI: 10.1021/jm00017a008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation