1HBV

A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC

1HBV の概要

• エントリーDOI: 10.2210/pdb1hbv/pdb
• 分子名称: HIV-1 PROTEASE, 2-[3-BENZYL-5-(1-ALANYL-AMINOETHYL)-2,3,6,7-TETRAHYDRO-1H-AZEPIN-1-YL]-1-OXOPROPYL-VALINYL-VALINE-METHYLESTER (3 entities in total)
• 機能のキーワード: hydrolase (acid protease)
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22193.29

構造登録者

Hoog, S.,Abdel-Meguid, S. (登録日: 1995-03-29, 公開日: 1995-07-10, 最終更新日: 2024-02-07)

• 主引用文献: Hoog, S.S.,Zhao, B.,Winborne, E.,Fisher, S.,Green, D.W.,DesJarlais, R.L.,Newlander, K.A.,Callahan, J.F.,Moore, M.L.,Huffman, W.F.,Abdel-Meguid, S.S.; A check on rational drug design: crystal structure of a complex of human immunodeficiency virus type 1 protease with a novel gamma-turn mimetic inhibitor.; J.Med.Chem., 38:3246-3252, 1995; PubMed: 7650677; DOI: 10.1021/jm00017a008

実験手法

X-RAY DIFFRACTION (2.3 Å)