1H8T

Echovirus 11

1H8T の概要

• エントリーDOI: 10.2210/pdb1h8t/pdb
• 分子名称: ECHOVIRUS 11 COAT PROTEIN VP1, ECHOVIRUS 11 COAT PROTEIN VP2, ECHOVIRUS 11 COAT PROTEIN VP3, ... (7 entities in total)
• 機能のキーワード: virus, echovirus coat protein, echovirus, icosahedral virus
• 由来する生物種: ECHOVIRUS 11; 詳細
• 細胞内の位置: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P29813 P29813 P29813 P29813
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95554.41

構造登録者

Stuart, A.,McKee, T.,Williams, P.A.,Harley, C.,Stuart, D.I.,Brown, T.D.K.,Lea, S.M. (登録日: 2001-02-15, 公開日: 2002-07-11, 最終更新日: 2023-12-13)

主引用文献

Stuart, A.,Mckee, T.,Williams, P.A.,Harley, C.,Shen, S.,Stuart, D.I.,Brown, T.D.K.,Lea, S.M.
Determination of the Structure of a Decay Accelerating Factor-Binding Clinical Isolate of Echovirus 11 Allows Mapping of Mutants with Altered Receptor Requirements for Infection
J.Virol., 76:7694-, 2002

PubMed Abstract: We have used X-ray crystallography to determine the structure of a decay accelerating factor (DAF)-binding, clinic-derived isolate of echovirus 11 (EV11-207). The structures of the capsid proteins closely resemble those of capsid proteins of other picornaviruses. The structure allows us to interpret a series of amino acid changes produced by passaging EV11-207 in different cell lines as highlighting the locations of multiple receptor-binding sites on the virion surface. We suggest that a DAF-binding site is located at the fivefold axes of the virion, while the binding site for a distinct but as yet unidentified receptor is located within the canyon surrounding the virion fivefold axes.

PubMed: 12097583
DOI: 10.1128/JVI.76.15.7694-7704.2002

実験手法

X-RAY DIFFRACTION (2.9 Å)