1H3Z

Solution structure of a PWWP domain from Schizosaccharomyces Pombe

1H3Z の概要

• エントリーDOI: 10.2210/pdb1h3z/pdb
• NMR情報: BMRB: 5538,5902
• 分子名称: HYPOTHETICAL 62.8 KDA PROTEIN C215.07C (1 entity in total)
• 機能のキーワード: nuclear protein, pwwp, chromatin, beta-barrel
• 由来する生物種: SCHIZOSACCHAROMYCES POMBE (FISSION YEAST)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12210.15

構造登録者

Slater, L.M.,Allen, M.D.,Bycroft, M. (登録日: 2002-09-23, 公開日: 2003-07-10, 最終更新日: 2024-05-15)

主引用文献

Slater, L.M.,Allen, M.D.,Bycroft, M.
Structural Variation in Pwwp Domains
J.Mol.Biol., 330:571-576, 2003

PubMed Abstract: The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.

PubMed: 12842472
DOI: 10.1016/S0022-2836(03)00470-4

実験手法

SOLUTION NMR