1H3P

STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS

「1GM3」から置き換えられました

1H3P の概要

• エントリーDOI: 10.2210/pdb1h3p/pdb
• 分子名称: ANTIBODY FAB FRAGMENT (3 entities in total)
• 機能のキーワード: immunoglobulin, antibody fab fragment
• 由来する生物種: MUS MUSCULUS (MOUSE); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49810.64

構造登録者

Pizarro, J.C.,Vulliez-Le-normand, B.,Riottot, M.M.,Budkowska, A.,Bentley, G.A. (登録日: 2002-09-12, 公開日: 2002-09-19, 最終更新日: 2024-10-09)

主引用文献

Pizarro, J.C.,Vulliez-Le-Normand, B.,Riottot, M.M.,Budkowska, A.,Bentley, G.A.
Structural and Functional Characterisation of a Monoclonal Antibody Specific for the Pres1 Region of Hepatitis B Virus
FEBS Lett., 509:463-, 2001

PubMed Abstract: The monoclonal antibody 5a19, raised against the ay serotype of hepatitis B virus, binds to the segment of the preS1 region comprising residues 37-43, which is implicated in attachment of the virus to hepatocytes. The dissociation constant, derived from kinetic studies using surface plasmon resonance techniques, is in the low nanomolar range. The nucleotide sequence of the variable domains has been determined and the corresponding germ-line genes have been identified. The three-dimensional structure of the Fab fragment has been determined by X-ray crystallography to 2.6 A resolution.

PubMed: 11749974
DOI: 10.1016/S0014-5793(01)03190-8

実験手法

X-RAY DIFFRACTION (2.6 Å)