1H2P

Human CD55 domains 3 & 4

1H2P の概要

• エントリーDOI: 10.2210/pdb1h2p/pdb
• 関連するPDBエントリー: 1H03 1H04 1H2Q 1M11
• 分子名称: COMPLEMENT DECAY-ACCELERATING FACTOR (1 entity in total)
• 機能のキーワード: immune system protein, complement decay accelerating factor, enteroviral receptor, bacterial receptor, ligand for cd97, complement pathway, alternative splicing, gpi-anchor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13585.06

構造登録者

Williams, P.,Chaudhry, Y.,Goodfellow, I.,Billington, J.,Spiller, B.,Evans, D.J.,Lea, S.M. (登録日: 2002-08-13, 公開日: 2003-03-20, 最終更新日: 2023-12-13)

主引用文献

Williams, P.,Chaudhry, Y.,Goodfellow, I.,Billington, J.,Powell, R.,Spiller, O.,Evans, D.J.,Lea, S.M.
Mapping Cd55 Function. The Structure of Two Pathogen-Binding Domains at 1.7 A
J.Biol.Chem., 278:10691-, 2003

PubMed Abstract: Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.

PubMed: 12499389
DOI: 10.1074/JBC.M212561200

実験手法

X-RAY DIFFRACTION (2.8 Å)