1H2N
Factor Inhibiting HIF-1 alpha
Summary for 1H2N
| Entry DOI | 10.2210/pdb1h2n/pdb |
| Related | 1H2K 1H2L 1H2M |
| Descriptor | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total) |
| Functional Keywords | transcription activator, oxidoreductase, oxygenase, hypoxia, hydroxylase |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Nucleus: Q9NWT6 |
| Total number of polymer chains | 1 |
| Total formula weight | 40818.41 |
| Authors | Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Schlemminger, I.,Seibel, J.F.,Schofield, C.J. (deposition date: 2002-08-12, release date: 2002-11-28, Last modification date: 2018-02-21) |
| Primary citation | Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Seibel, J.F.,Schlemminger, I.,Pugh, C.,Ratcliffe, P.,Schofield, C.J. Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha J.Biol.Chem., 278:1802-1806, 2003 Cited by PubMed: 12446723DOI: 10.1074/JBC.C200644200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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