1GXF
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH THE INHIBITOR QUINACRINE MUSTARD
Summary for 1GXF
Entry DOI | 10.2210/pdb1gxf/pdb |
Related | 1AOG 1NDA |
Descriptor | TRYPANOTHIONE REDUCTASE (OXIDIZED FORM), FLAVIN-ADENINE DINUCLEOTIDE, MALEIC ACID, ... (5 entities in total) |
Functional Keywords | oxidoreductase, trypanothione reductase, fad dependent, disulphide oxidoreductase, quinacrine mustard, inhibitor, redox-active center, flavoprotein, fad, nadp |
Biological source | TRYPANOSOMA CRUZI |
Cellular location | Cytoplasm: P28593 |
Total number of polymer chains | 2 |
Total formula weight | 111413.90 |
Authors | Bond, C.S.,Peterson, M.R.,Vickers, T.J.,Fairlamb, A.H.,Hunter, W.N. (deposition date: 2002-04-04, release date: 2004-05-06, Last modification date: 2023-12-13) |
Primary citation | Saravanamuthu, A.,Vickers, T.J.,Bond, C.S.,Peterson, M.R.,Hunter, W.N.,Fairlamb, A.H. Two Interacting Binding Sites for Quinacrine Derivatives in the Active Site of Trypanothione Reductase: A Template for Drug Design J.Biol.Chem., 279:29493-, 2004 Cited by PubMed: 15102853DOI: 10.1074/JBC.M403187200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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