1GUE

SENSORY RHODOPSIN II

1GUE の概要

• エントリーDOI: 10.2210/pdb1gue/pdb
• 関連するPDBエントリー: 1GU8 1H68 1JGJ
• 分子名称: SENSORY RHODOPSIN II, RETINAL, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: archaeal rhodopsin, photoreceptor, phototaxis
• 由来する生物種: NATRONOMONAS PHARAONIS (NATRONOBACTERIUM PHARAONIS)
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P42196
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25688.70

構造登録者

Edman, K.,Royant, A.,Nollert, P.,Maxwell, C.A.,Pebay-Peyroula, E.,Navarro, J.,Neutze, R.,Landau, E.M. (登録日: 2002-01-24, 公開日: 2002-04-12, 最終更新日: 2024-11-20)

主引用文献

Edman, K.,Royant, A.,Nollert, P.,Maxwell, C.A.,Pebay-Peyroula, E.,Navarro, J.,Neutze, R.,Landau, E.M.
Early Structural Rearrangements in the Photocycle of an Integral Membrane Sensory Receptor
Structure, 10:473-, 2002

PubMed Abstract: Sensory rhodopsins are the primary receptors of vision in animals and phototaxis in microorganisms. Light triggers the rapid isomerization of a buried retinal chromophore, which the protein both accommodates and amplifies into the larger structural rearrangements required for signaling. We trapped an early intermediate of the photocycle of sensory rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and determined its X-ray structure to 2.3 A resolution. The observed structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's beta-ionone ring undergoing a prominent movement. Comparison with the early structural rearrangements of bacteriorhodopsin illustrates how modifications in the retinal binding pocket of pSRII allow subtle differences in the early relaxation of photoisomerized retinal.

PubMed: 11937052
DOI: 10.1016/S0969-2126(02)00736-0

実験手法

X-RAY DIFFRACTION (2.27 Å)