1GTP

GTP CYCLOHYDROLASE I

1GTP の概要

• エントリーDOI: 10.2210/pdb1gtp/pdb
• 分子名称: GTP CYCLOHYDROLASE I, SULFATE ION (3 entities in total)
• 機能のキーワード: gtp, purine hydrolysis, pterine synthesis, hydrolase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 20
• 化学式量合計: 496590.28

構造登録者

Nar, H.,Huber, R.,Meining, W.,Bacher, A. (登録日: 1995-09-16, 公開日: 1996-11-08, 最終更新日: 2024-10-23)

主引用文献

Nar, H.,Huber, R.,Meining, W.,Schmid, C.,Weinkauf, S.,Bacher, A.
Atomic structure of GTP cyclohydrolase I.
Structure, 3:459-466, 1995

PubMed Abstract: Tetrahydrobiopterin serves as the cofactor for enzymes involved in neurotransmitter biosynthesis and as regulatory factor in immune cell proliferation and the biosynthesis of melanin. The biosynthetic pathway to tetrahydrobiopterin consists of three steps starting from GTP. The initial reaction is catalyzed by GTP cyclohdrolase I (GTP-CH-I) and involves the chemically complex transformation of the purine into the pterin ring system.

PubMed: 7663943
DOI: 10.1016/S0969-2126(01)00179-4

実験手法

X-RAY DIFFRACTION (3 Å)