1GRH
INHIBITION OF HUMAN GLUTATHIONE REDUCTASE BY THE NITROSOUREA DRUGS 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA AND 1-(2-CHLOROETHYL)-3-(2-HYDROXYETHYL)-1-NITROSOUREA
Summary for 1GRH
Entry DOI | 10.2210/pdb1grh/pdb |
Related | 1GRG |
Descriptor | GLUTATHIONE REDUCTASE, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, flavoenzyme |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390 |
Total number of polymer chains | 1 |
Total formula weight | 52562.83 |
Authors | Karplus, P.A.,Schulz, G.E. (deposition date: 1992-12-15, release date: 1994-01-31, Last modification date: 2024-06-05) |
Primary citation | Karplus, P.A.,Krauth-Siegel, R.L.,Schirmer, R.H.,Schulz, G.E. Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis. Eur.J.Biochem., 171:193-198, 1988 Cited by PubMed: 3338461DOI: 10.1111/j.1432-1033.1988.tb13775.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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