1GP0

Human IGF2R domain 11

1GP0 の概要

• エントリーDOI: 10.2210/pdb1gp0/pdb
• 関連するPDBエントリー: 1E6F 1GP3
• 分子名称: CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, SULFATE ION (3 entities in total)
• 機能のキーワード: receptor, insulin-like growth factor, cation independent mannose 6-phosphate, transport, beta barrel
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15660.74

構造登録者

Brown, J.,Esnouf, R.M.,Jones, M.A.,Linnell, J.,Harlos, K.,Hassan, A.B.,Jones, E.Y. (登録日: 2001-10-29, 公開日: 2002-02-28, 最終更新日: 2024-11-13)

主引用文献

Brown, J.,Esnouf, R.M.,Jones, M.A.,Linnell, J.,Harlos, K.,Hassan, A.B.,Jones, E.Y.
Structure of a Functional Igf2R Fragment Determined from the Anomalous Scattering of Sulfur
Embo J., 21:1054-, 2002

PubMed Abstract: Insulin-like growth factor II receptor (IGF2R) is a multifunctional cell surface receptor implicated in tumour suppression. Its growth inhibitory activity has been associated with an ability to bind IGF-II. IGF2R contains 15 homologous extracellular domains, with domain 11 primarily responsible for IGF-II binding. We report a 1.4 A resolution crystal structure of domain 11, solved using the anomalous scattering signal of sulfur. The structure consists of two crossed beta-sheets forming a flattened beta-barrel. Structural analysis identifies the putative IGF-II binding site at one end of the beta-barrel whilst crystal lattice contacts suggest a model for the full-length IGF2R extracellular region. The structure factors and coordinates of IGF2R domain 11 have been deposited in the Protein Data Bank (accession codes 1GP0 and 1GP3).

PubMed: 11867533
DOI: 10.1093/EMBOJ/21.5.1054

実験手法

X-RAY DIFFRACTION (1.4 Å)