1GNH

HUMAN C-REACTIVE PROTEIN

1GNH の概要

• エントリーDOI: 10.2210/pdb1gnh/pdb
• 分子名称: C-REACTIVE PROTEIN, CALCIUM ION (2 entities in total)
• 機能のキーワード: pentraxin, acute-phase reactant, acute-phase protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02741
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 231321.64

構造登録者

Shrive, A.K.,Cheetham, G.M.T.,Holden, D.,Myles, D.A.,Turnell, W.G.,Volanakis, J.E.,Pepys, M.B.,Bloomer, A.C.,Greenhough, T.J. (登録日: 1996-03-01, 公開日: 1997-01-27, 最終更新日: 2024-11-13)

主引用文献

Shrive, A.K.,Cheetham, G.M.,Holden, D.,Myles, D.A.,Turnell, W.G.,Volanakis, J.E.,Pepys, M.B.,Bloomer, A.C.,Greenhough, T.J.
Three dimensional structure of human C-reactive protein.
Nat.Struct.Biol., 3:346-354, 1996

PubMed Abstract: The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role.

PubMed: 8599761
DOI: 10.1038/nsb0496-346

実験手法

X-RAY DIFFRACTION (3 Å)