1GMY

Cathepsin B complexed with dipeptidyl nitrile inhibitor

Summary for 1GMY

Entry DOI	10.2210/pdb1gmy/pdb
Related	1CSB 1HUC 1PBH 2PBH 3PBH
Descriptor	CATHEPSIN B, 2-AMINOETHANIMIDIC ACID, 3-METHYLPHENYLALANINE, ... (5 entities in total)
Functional Keywords	hydrolase/inhibitor, complex (hydrolase-inhibitor), covalent complex, protease, cathepsin b, hydrolase, thiol protease, hydrolase-inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Lysosome : P07858
Total number of polymer chains	3
Total formula weight	87812.00
Authors	Greenspan, P.D.,Clark, K.L.,Tommasi, R.A.,Cowen, S.D.,McQuire, L.W.,Farley, D.L.,van Duzer, J.H.,Goldberg, R.L.,Zhou, H.,Du, Z.,Fitt, J.J.,Coppa, D.E.,Fang, Z.,Macchia, W.,Zhu, L.,Capparelli, M.P.,Goldstein, R.,Wigg, A.M.,Doughty, J.R.,Bohacek, R.S.,Knap, A.K. (deposition date: 2001-09-25, release date: 2002-09-19, Last modification date: 2017-07-05)
Primary citation	Greenspan, P.D.,Clark, K.L.,Tommasi, R.A.,Cowen, S.D.,Mcquire, L.W.,Farley, D.L.,Van Duzer, J.H.,Goldberg, R.L.,Zhou, H.,Du, Z.,Fitt, J.J.,Coppa, D.E.,Fang, Z.,Macchia, W.,Zhu, L.,Capparelli, M.P.,Goldstein, R.,Wigg, A.M.,Doughty, J.R.,S Bohacek, R.,Knap, A.K. Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design J.Med.Chem., 44:4524-, 2001 Cited by PubMed: 11741472 DOI: 10.1021/JM010206Q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation