1GMO
CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR
1GMO の概要
エントリーDOI | 10.2210/pdb1gmo/pdb |
関連するPDBエントリー | 1BHT 1GMN 1GP9 1NK1 1SHY 1SI5 2CED 2CEE 2CEG 2HGF |
分子名称 | HEPATOCYTE GROWTH FACTOR, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... (9 entities in total) |
機能のキーワード | hormone, growth factor |
由来する生物種 | HOMO SAPIENS (HUMAN) |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 184296.00 |
構造登録者 | Lietha, D.,Chirgadze, D.Y.,Mulloy, B.,Blundell, T.L.,Gherardi, E. (登録日: 2001-09-20, 公開日: 2001-10-02, 最終更新日: 2023-12-13) |
主引用文献 | Lietha, D.,Chirgadze, D.Y.,Mulloy, B.,Blundell, T.L.,Gherardi, E. Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor Embo J., 20:5543-, 2001 Cited by PubMed: 11597998DOI: 10.1093/EMBOJ/20.20.5543 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3 Å) |
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