1GMN

CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR

1GMN の概要

• エントリーDOI: 10.2210/pdb1gmn/pdb
• 分子名称: HEPATOCYTE GROWTH FACTOR, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: hgf/sf, hormone/growth factor, hormone-growth factor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44252.27

構造登録者

Lietha, D.,Chirgadze, D.Y.,Mulloy, B.,Blundell, T.L.,Gherardi, E. (登録日: 2001-09-19, 公開日: 2001-10-02, 最終更新日: 2023-12-13)

• 主引用文献: Lietha, D.,Chirgadze, D.Y.,Mulloy, B.,Blundell, T.L.,Gherardi, E.; Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor; Embo J., 20:5543-, 2001; PubMed: 11597998; DOI: 10.1093/EMBOJ/20.20.5543

実験手法

X-RAY DIFFRACTION (2.3 Å)