1GI9
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
1GI9 の概要
エントリーDOI | 10.2210/pdb1gi9/pdb |
関連するPDBエントリー | 1C5X |
分子名称 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR, 2-(2-HYDROXY-5-METHOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, CITRIC ACID, ... (5 entities in total) |
機能のキーワード | three-centered, very short hydrogen bond, oxyanion hole water, shift of pka of his57, structure-based drug design, specificity, urokinase, trypsin, thrombin, zn+2-mediated inhibition, blood clotting, hydrolase |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Secreted: P00749 P00749 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 30955.21 |
構造登録者 | Katz, B.A.,Elrod, K.,Luong, C.,Rice, M.,Mackman, R.L.,Sprengeler, P.A.,Spencer, J.,Hatayte, J.,Janc, J.,Link, J.,Litvak, J.,Rai, R.,Rice, K.,Sideris, S.,Verner, E.,Young, W. (登録日: 2001-01-22, 公開日: 2002-01-22, 最終更新日: 2023-12-27) |
主引用文献 | Katz, B.A.,Elrod, K.,Luong, C.,Rice, M.J.,Mackman, R.L.,Sprengeler, P.A.,Spencer, J.,Hataye, J.,Janc, J.,Link, J.,Litvak, J.,Rai, R.,Rice, K.,Sideris, S.,Verner, E.,Young, W. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J.Mol.Biol., 307:1451-1486, 2001 Cited by PubMed: 11292354DOI: 10.1006/jmbi.2001.4516 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
構造検証レポート
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