1GI5
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Summary for 1GI5
Entry DOI | 10.2210/pdb1gi5/pdb |
Related | 1C5R |
Descriptor | BETA-TRYPSIN, CALCIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | three-centered, very short hydrogen bond, oxyanion hole water, shift of pka of his57, structure-based drug design, specificity, urokinase, trypsin, thrombin, zn+2-mediated inhibition, hydrolase |
Biological source | Bos taurus (cattle) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 23839.80 |
Authors | Katz, B.A.,Elrod, K.,Luong, C.,Rice, M.,Mackman, R.L.,Sprengeler, P.A.,Spencer, J.,Hatayte, J.,Janc, J.,Link, J.,Litvak, J.,Rai, R.,Rice, K.,Sideris, S.,Verner, E.,Young, W. (deposition date: 2001-01-22, release date: 2002-01-22, Last modification date: 2023-12-27) |
Primary citation | Katz, B.A.,Elrod, K.,Luong, C.,Rice, M.J.,Mackman, R.L.,Sprengeler, P.A.,Spencer, J.,Hataye, J.,Janc, J.,Link, J.,Litvak, J.,Rai, R.,Rice, K.,Sideris, S.,Verner, E.,Young, W. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J.Mol.Biol., 307:1451-1486, 2001 Cited by PubMed: 11292354DOI: 10.1006/jmbi.2001.4516 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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