1GHQ

CR2-C3D COMPLEX STRUCTURE

Summary for 1GHQ

• Entry DOI: 10.2210/pdb1ghq/pdb
• Descriptor: COMPLEMENT C3, CR2/CD121/C3D/EPSTEIN-BARR VIRUS RECEPTOR, ZINC ION, ... (5 entities in total)
• Functional Keywords: cr2, c3d, immune system-viral protein receptor complex, immune system/viral protein receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01024; Membrane; Single-pass type I membrane protein: P20023
• Total number of polymer chains: 3
• Total formula weight: 64491.46

Authors

Szakonyi, G.,Guthridge, J.M.,Li, D.,Holers, V.M.,Chen, X.S. (deposition date: 2001-01-11, release date: 2001-06-13, Last modification date: 2023-12-27)

Primary citation

Szakonyi, G.,Guthridge, J.M.,Li, D.,Young, K.,Holers, V.M.,Chen, X.S.
Structure of complement receptor 2 in complex with its C3d ligand.
Science, 292:1725-1728, 2001

PubMed Abstract: Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

PubMed: 11387479
DOI: 10.1126/science.1059118

Experimental method

X-RAY DIFFRACTION (2.04 Å)