1GGQ

OUTER SURFACE PROTEIN C (OSPC) OF BORRELIA BURGDORFERI STRAIN B31

1GGQ の概要

• エントリーDOI: 10.2210/pdb1ggq/pdb
• 関連するPDBエントリー: 1F1M 1FJ1 1OSP
• 分子名称: OUTER SURFACE PROTEIN C, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: lyme disease antigen, helical bundle, homodimer, membrane protein
• 由来する生物種: Borrelia burgdorferi
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 74413.71

構造登録者

Dunn, J.J.,Lawson, C.L. (登録日: 2000-09-14, 公開日: 2001-03-14, 最終更新日: 2024-05-22)

主引用文献

Kumaran, D.,Eswaramoorthy, S.,Luft, B.J.,Koide, S.,Dunn, J.J.,Lawson, C.L.,Swaminathan, S.
Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.
EMBO J., 20:971-978, 2001

PubMed Abstract: Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been determined for strains HB19 and B31 to 1.8 and 2.5 A resolution, respectively. The three-dimensional structure is predominantly helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spirochetes are residing in the midgut of unfed ticks, which is mostly beta-sheet. The surface of OspC that would project away from the spirochete's membrane has a region of strong negative electrostatic potential which may be involved in binding to positively charged host ligands. This feature is present only on OspCs from strains known to cause invasive human disease.

PubMed: 11230121
DOI: 10.1093/emboj/20.5.971

実験手法

X-RAY DIFFRACTION (2.51 Å)