1GAR

TOWARDS STRUCTURE-BASED DRUG DESIGN: CRYSTAL STRUCTURE OF A MULTISUBSTRATE ADDUCT COMPLEX OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE AT 1.96 ANGSTROMS RESOLUTION

1GAR の概要

• エントリーDOI: 10.2210/pdb1gar/pdb
• 分子名称: GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, N-[4-[[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-4-PYRIMIDINYL)-PROPYL]-[2-((2-OXO-2-((4-PHOSPHORIBOXY)-BUTYL)-AMINO)-ETHYL)-THIO-ACETYL]-AMINO]BENZOYL]-1-GLUTAMIC ACID (3 entities in total)
• 機能のキーワード: transferase (formyl)
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47963.85

構造登録者

Wilson, I.A.,Klein, C.,Chen, P.,Arevalo, J.H. (登録日: 1994-12-08, 公開日: 1995-07-10, 最終更新日: 2024-02-07)

• 主引用文献: Klein, C.,Chen, P.,Arevalo, J.H.,Stura, E.A.,Marolewski, A.,Warren, M.S.,Benkovic, S.J.,Wilson, I.A.; Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.; J.Mol.Biol., 249:153-175, 1995; PubMed: 7776369; DOI: 10.1006/jmbi.1995.0286

実験手法

X-RAY DIFFRACTION (1.96 Å)